NOTICE: You should know that if you have allergic reactions to different substances, your reactions may be worse while you are using metoprolol, and your allergic reactions may not respond to the usual doses of injectable epinephrine. Additionally, alcohol can add to the drowsiness caused by this medication. Do not drive a car or operate machinery until you know how this medication affects you. If you are having surgery, including dental surgery, you should inform the doctor or dentist that you are taking metoprolol. If you become pregnant while taking metoprolol, call your doctor. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.įurthermore, you should let your doctor know if you have or have ever had asthma or other lung disease, a slow heart rate, heart or liver disease, diabetes, or an overactive thyroid gland (hyperthyroidism). Be sure to mention any of the following: fluoxetine ( Prozac ®, Sarafem ®) paroxetine ( Paxil ®) propafenone ( Rythmol ®) quinidine ( Quinidex ®) and reserpine ( Serpalan ®, Serpasil ®, Serpatab ®). Inform your doctor and pharmacist what prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking. Please tell your doctor and pharmacist if you are allergic to metoprolol or any other medications. What special precautions should I follow? It may take a few weeks before you feel the full benefit of metoprolol, and until you speak with your doctor you should continue to take metoprolol even if you feel well. So too, the extended-release metoprolol controls heart failure but does not cure it. Please note that metoprolol controls high blood pressure and angina but does not cure them. Your doctor may start you on a low dose of metoprolol and gradually increase your dose. Swallow the whole or half tablets whole, and do not chew or crush them.

Excretion Metoprolol: half life elimination: 3-8 hours excreted via urine (<5-10 as unchanged drug). Hydrochlorothiazide: not metabolized bioavailability: 50-80. Moreover, do not take more or less of it or take it more often than prescribed by your doctor. Metoprolol: extensively 1st pass hepatic metabolism via CYP2D6 bioavailability: approx 50. To help you remember to take metoprolol, take it around the same time every day.įollow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. The extended-release tablet is usually taken once a day. The regular tablet is usually taken once or twice a day with meals or immediately after meals. Metoprolol comes as a tablet and an extended-release tablet to be taken orally.

Half life of metoprolol